February 18, 2017

Article Published in the Journal of Clinical Pharmacology!

Population Pharmacokinetic Modeling of Armodafinil and Its Major Metabolites (abstract)

Authors:  Willavize S(1), Fiedler-Kelly J(1), Ludwig E(1), Guan L(2). 

1 Cognigen Corporation, Buffalo, NY, USA.
2 Teva Pharmaceuticals, Frazer, PA, USA.

Citation: J Clin Pharmacol. 2017;57(2):255-65

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October 24, 2016

4 Posters being Presented at the 7th Annual American Conference of Pharmacometricians

4 Posters are being presented at the 7th Annual American Conference of Pharmacometricians in Bellevue, Washington.

Sunkaraneni S, Bihorel S, Ludwig E, Fiedler-Kelly J, Morris D, Hopkins S, Gallupi G, Blum D. Case study: modeling and simulation strategy to support eslicarbazepine acetate (ESL) development in pediatric patients in the treatment of partial-onset seizures. Poster presented at: Seventh American Conference on Pharmacometrics (ACoP7); Pre-conference: Interactive Session on Pharmacometrics Applications to Pediatric Drug Development; October 23 , 2016; Bellevue, Washington.

Sunkaraneni S, Passarell JA, Ludwig E, Pitner J, Grinnell T, Blum D. Pharmacokinetic-pharmacodynamic modeling and simulation to predict efficacy outcomes with eslicarbazepine acetate 800 mg once daily as monotherapy for partial-onset seizures. Poster presented at: Seventh American Conference on Pharmacometrics (ACoP7); October 23-26, 2016; Bellevue, Washington.

Phillips L, Raddad E. Interactive code for guiding dose selection. Poster presented at: Seventh American Conference on Pharmacometrics (ACoP7); October 23-26, 2016; Bellevue, Washington. Click here for Supplemental Berkley Madonna Code.

Macwan JS, Fraczkiewicz G, Bolger MB, Lukacova V, Woltosz WS. Prediction of Metabolic Interactions with Atazanavir through UGT1A1 Inhibition using a Physiologically Based Pharmacokinetic Model.

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October 24, 2016

Jill Fiedler-Kelly Awarded Fellow Status in ISoP

Jill Fiedler-Kelly, Vice President, Pharmacometric Services was awarded fellow status in the International Society of Pharmacometricians at the 7th Annual American Conference of Pharmacometricians in Bellevue, Washington, along with her esteemed colleagues:  Dr. Bill Jusko, Distinguished Professor of Pharmaceutical Sciences at University at Buffalo, Dr. Matts Karlson, Professor,  Pharmaceutical Biosciences at University of Uppsala; and Dr. Nick Holford, Professor, Clinical Pharamcology, University of Auckland. 

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July 10, 2016

Register for a Hands-On Introductory Workshop in Population PK Data Analysis with NONMEM and KIWI!

Register Here!

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May 21, 2016

Two posters presented at 2016 APA Conference in Atlanta, GA.

Two posters presented at the 169th Annual Meeting of the American Psychiatric Association (APA), May 14-18, 2016; Atlanta, Georgia by our colleagues at Allergan along with Cognigen authors and their collective expertise in the area of psychotherapeutic agents. The pharmacokinetics of cariprazine and its major metabolites were characterized utilizing a population approach of pooling pharmacokinetic data from 13 studies. Further exposure-response relationships were presented in subjects with schizophrenia or bipolar disorder.  
See here for the PK poster.  See here for the PK/PD poster.

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May 21, 2016

Poster presented at 2016 ATS Conference in San Francisco,CA.

A poster presented at the American Thoracic Society (ATS) International Congress, May 13–18, 2016, San Francisco, CA USA by our colleagues at Teva along with Cognigen authors and their collective expertise in the area of pulmonary disease. Pharmacokinetic modeling and simulations were used to support weight-based dosing for intravenous reslizumab.
See the poster here

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May 5, 2016

Article Published in Brazilian Journal of Infectious Diseases!

Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections.  (Abstract)

Authors: Ortiz-Covarrubias A, Fang E, Prokocimer PG, Flanagan SD, Zhu X, Cabré-Márquez JF, Tanaka T, Passarell J, Fiedler-Kelly J, Nannini EC. 

Citation: Braz J Infect Dis. 2016;20(2):184–192.

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April 16, 2016

Simulations Plus Releases DDDPlus Version 5.0

Simulations Plus Releases DDDPlus Version 5.0, Release adds significant enhancements to unique software product

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April 16, 2016

Poster presented at 2016 AAN Conference in Vancover BC, Canada

A poster presented at the American Academy of Neurology (AAN) Annual Meeting, April 15–21 2016, Vancouver, BC, Canada by our colleagues at Sunovion along with Cognigen authors and their collective expertise in the area of epilepsy. Pharmacokinetic-pharmacodynamic modeling and simulations were used to predict efficacy outcomes with eslicarbazepine acetate 800 mg once daily as monotherapy . See the poster here

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March 10, 2016

Visit us at the ASCPT Meeting in San Diego, CA

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