NONMEM Discussion List - Index

The following topics have been discussed on the NONMEM discussion list from Apr 1995 - Dec 2006:

1 Subject: [NMusers] geometric mean of parameter estimates

2 Subject: [NMusers] Pediatric Collaborators Sought

3 Subject: [NMusers] MAXIDS=10000

4 Subject: [NMusers] Wings for NONMEM Version 600 for NONMEM VI

5 Subject: [NMusers] Distribution of NONMEM VI

6 Subject: [NMusers] is PDx-Pop 2.0a compatible with NONMEM VI?

7 Subject: [NMusers] Welcome to the new small sample size world of NONMEM VI

8 Subject: [NMusers] Intel/Compaq/Digital Fortran Compiler installation issues related to NONMEM and PDx-Pop

9 Subject: [NMusers] simulation problem

10 Subject: [NMusers] NONMEM Modeling of Plasma + Urine Data

11 Subject: [NMusers] Full and Reduced Residual Error Models

12 Subject: [NMusers] Phase III trail popPK sample size

13 Subject: [NMusers] Con't: fast and slow absorption

14 Subject: [NMusers] modelling lag time and absorption

15 Subject: [NMusers] Help on rounding error ( error=134) !

16 Subject: [NMusers] Getting PRED and WRES

17 Subject: [NMusers] NONMEM sparse data advantage reference

18 Subject: [NMusers] covariate model building: forward inclusion and backward elimination

19 Subject: [NMusers] sequential PKPD modeling

20 Subject: [NMusers] omega and mixture

21 Subject: [NMusers] WinPOPT Release 1.1 beta now available

22 Subject: [NMusers] PRED in $TABLE from rich and sparse data

23 Subject: [NMusers] Some basic modeling results

24 Subject: [NMusers] ANN: Census 1.0b1

25 Subject: [NMusers] systematic difference

26 Subject: [NMusers] Outlier in subject level


28 Subject: [NMusers] Bootstrap question

29 Subject: [NMusers] NONMEM

30 Subject: [NMusers] importData in S as numeric format

31 Subject: [NMusers] NONMEM VI Progress Update

32 Subject: [NMusers] Can we increase maximum number of function evaluations?

33 Subject: [NMusers] Time to event variable

34 Subject: [NMusers] Transference of data into NONMEM

35 Subject: [NMusers] Optimal study design software available now

36 Subject: [NMusers] Automated NONMEM model selection patent issued

37 Subject: [NMusers] How to determine the initial estimates?Thanks

38 Subject: [NMusers] Can NONMEM compute all pharmacokinetics parameters ?

39 Subject: [NMusers] different results from two computers

40 Subject: [NMusers] A question about Xpose!

41 Subject: [NMusers] Hi,dear all ,some new questions occur !

42 Subject: [NMusers] How can I determine cl=theta1 or v=theta1?

43 Subject: [NMusers] How could I determine which thetan(n=1,2,3...) will be put to K or CL?

44 Subject: Subject: [NMusers] Using BLQ data for SIGMA

45 Subject: [NMusers] Error when combining proportional residual error,

46 Subject: [NMusers] Problems with an apparent compiler-senstive model

47 Subject: [NMusers] Xpose updated

48 Subject: [NMusers] Reporting of interim models in Pop PK Reports

49 Subject: [NMusers] EMEA pop pk reporting

50 Subject: [NMusers] SS indication for dataset with BID dose and AM dose different from PM dose.

51 Subject: [NMusers] covariance step aborted.

52 Subject: [NMusers] Multiple dose analysis using NONMEM

53 Subject: [NMusers] Covariate models of genetic polymorphisms

54 Subject: Re: [NMusers] likelihood model for missing SEX data

55 Subject: [NMusers] ADVAN6..

56 Subject: [NMusers] logistic regression: NONMEM LAPLACIAN vs. Gaussian quadrature

57 Subject: [NMusers] Sad News

58 Subject: [NMusers] Simulation of Steady state concentration of Phenytoin

59 Subject: [NMusers] Mixture of Distributions Modeling of A PD Variable

60 Subject: [NMusers] Xpose 4.0 PR3 released

61 Subject: [NMusers] Referenced memory could not be written error

62 Subject: [NMusers] Dose optimization in drug development (Rajesh Krishna)

63 Subject: [NMusers] leverage analysis vs. case deletion

64 Subject: [NMusers] Placebo in indirect PD models

65 Subject: [NMusers] Xpose 4.0

66 Subject: [NMusers] Installation of NONMEM using NMQual.

67 Subject: [NMusers] Weighting in NONMEM

68 Subject: [NMusers] ADAPT II with SAMPLE option

69 Subject: [NMusers] $ERROR Block: Target mediated disposition

70 Subject: [NMusers] NONMEM graphics

71 Subject: [NMusers] What are the best studies to combine?

72 Subject: [NMusers] GAM analysis and further action

73 Subject: [NMusers] restraining eta code

74 Subject: [NMusers] ADVAN6 coding question

75 Subject: [NMusers] Effect of FOCE vs FOCE INTER on success of covariance step within a model with additive error

76 Subject: [NMusers] Help on a cell transit model

77 Subject: [NMusers] Compaq Visual Fortran 6.6

78 Subject: [NMusers] Sample size requirement for POP PK analysis to identify drug interactions

79 Subject: [NMusers] Sequential PK/PD approach Query

80 Subject: [NMusers] unit of weighted residual

81 Subject: [NMusers] Single Precision NONMEM

82 Subject: [NMusers] interoccasion variability

83 Subject: [NMusers] 100% CPU with NONMEM

84 Subject: [NMusers] Where to download Population Fisher Information Matrix?

85 Subject: [NMusers] NONMEM

86 Subject: [NMusers] PD modeling of dataset with opposite values in the measurement effect

87 Subject: [NMusers] Very sad news.

88 Subject: [NMusers] covariate selection question

89 Subject: [NMusers] ka and Duration

90 Subject: [NMusers] line length limit of NMTRAN and initial value limit of NONMEM

91 Subject: [NMusers] question of $INPUT: NO. OF DATA ITEMS EXCEEDS 20

92 Subject: [NMusers] Optimal Design Software

93 Subject: [NMusers] Have you run NONMEM on a G5 Macintosh?

94 Subject: [NMusers] PD modeling: What is the most efficient approach to transfer data?

95 Subject: [NMusers] NM mixture model with three subgroups

96 Subject: [NMusers] Revised NMTRAN Bug List [01DEC2005]

97 Subject: [NMusers] Looking for faster CPU

98 Subject: [NMusers] software for transpose

99 Subject: [NMusers] Models for Ordered Categorical Pharmacodynamic Data

100 Subject: [NMusers] Excel File Import Error

101 Subject: [NMusers] Win64

102 Subject: [NMusers] processor choice

103 Subject: [NMusers] Distribution of Simulated Cmax

104 Subject: [NMusers] MIXTURE modeling

105 Subject: [NMusers] Incorporating duplicate assays

106 Subject: [NMusers] FW: question for absorption modeling

107 Subject: [NMusers] DOS emulation window issue

108 Subject: [NMusers] the number of records in one individual

109 Subject: [NMusers] Nonmem install problem

110 Subject: [NMusers] target-mediated model - steady state - unstable system?

111 Subject: [NMusers] Setting up CPU Affinity on Linux

112 Subject: [NMusers] Inclusion of covariates and model improvement

113 Subject: [NMusers] 3 questions

114 Subject: [NMusers] difficulty with FOCE

115 Subject: [NMusers] non-linear PK

116 Subject: [NMusers] associatin/dissociation model

117 Subject: [NMusers] MM elimination vs dose

118 Subject: machine=AMD-64

119 Subject: [NMusers] Dose and concentration unit differences

120 Subject: [NMusers] Problems with recursive PRED models...

121 Subject: [NMusers] new networking group for Modeling and Simulation

122 Subject: [NMusers] Calculation of the 90% CI values from pop PK model estimates

123 Subject: [NMusers] Interpreting IOV

124 Subject: [NMusers] Covariance: Matrix=S or Matrix=R

125 Subject: [NMusers] Question about error message regarding invalid MDV field

126 Subject: [NMusers] FW: revised NONMEM bug list [31AUG2005]

127 Subject: [NMusers] FYI: end of Compaq support for Compaq Visual Fortran

128 Subject: [NMusers] gcc and ADVAN5 -7

129 Subject: [NMusers] Using CONT data item

130 Subject: [NMusers] Installation error message.

131 Subject: [NMusers] problems with df.txt file?

132 Subject: [NMusers] exceeding max. number of INPUT-variables

133 Subject: [NMusers] raised globulin levels in diabetics

134 Subject: [NMusers] post hoc pk parameter associations with clinical covariates/response

135 Subject: [NMusers] bias and good fit vs centering

136 Subject: [NMusers] Upgrading to Intel 9.0 Fortran for Windows

137 Subject: [NMusers] PRIOR Subroutine

138 Subject: [NMusers] faster PC to run nmv

139 Subject: [NMusers] Simulating different populations

140 Subject: [NMusers] Part 11 compliance

141 Subject: [NMusers] Where's my email?

142 Subject: [NMusers] Standard errors below 0.1%?

143 Subject: [NMusers] initial evaluation of S-Plus 7.0?

144 Subject: [NMusers] NONMEMory => Census

145 Subject: [NMusers] log transformed data and multi compartment PK

146 Subject: [NMusers] Release of NONMEMory

147 Subject: [NMusers] Failing table step upon redefining ETAs as additive (or high correlations in $COV output)


149 Subject: [NMusers] Revision to NONMEM Tip #20 July 18, 2005

150 Subject: [NMusers] NONMEM bug XV correction to NONMEM bug list [23MAY2005] --> revised 18July2005

151 Subject: [NMusers] End of semester MCQ and short answer question

152 Subject: [NMusers] Journals

153 Subject: [NMusers] new contact information (phone and snail mail) for nmconsult

154 Subject: [NMusers] guideline on data exclusion?

155 Subject: [NMusers] statistical basis of NONMEM

156 Subject: [NMusers] Model selection criteria?

157 Subject: [NMusers] POSTHOC and ETA values disagree

158 Subject: [NMusers] 202 Fortran Error Message with LOG()

159 Subject: [NMusers] NONMEM Tips #22 - June 20, 2005 - Upgrading to Intel 9.0Fortran for Windows

160 Subject: [NMusers] Compaq Digital Fortran no more

161 Subject: [NMusers] Simulation vs. actual data

162 Subject: [NMusers] Help!!!

163 Subject: [NMusers] NONMEM mathematical background

164 Subject: [NMusers] From NMUser

165 Subject: [NMusers] What does nonmem do after iteration stops?

166 Subject: [NMusers] updated NONMEM bug list [23MAY2005]

167 Subject: [NMusers] RES and WRES

168 Subject: [NMusers] CONT data item tip

169 Subject: [NMusers] a question about control file

170 Subject: [NMusers] Neutrophil transit models

171 Subject: [NMusers] Need help

172 Subject: [NMusers] NP4F error

173 Subject: [NMusers] Multiple dosing

174 Subject: [NMusers] Site announcement

175 Subject: [NMusers] Users access control...

176 Subject: [NMusers] questions re: modeling in industry

177 Subject: [NMusers] Probabilistic model

178 Subject: [NMusers] NONMEM Tips #21 - May 13, 2005 - Using more than one line perdat a record -> using more than 20 data items

179 Subject: [NMusers] SD values

180 Subject: [NMusers] between-patient variability in PK and PD

181 Subject: [NMusers] Iterative Two Stage Bayesian in NONMEM

182 Subject: [NMusers] Missing mixed continuous and categorical data

183 Subject: [NMusers] ADVAN5 code

184 Subject: [NMusers] erros messages related to data file and/or NONMEM I/O

185 Subject: [NMusers] Model building advice

186 Subject: [NMusers] Launch of the Free Web Based Pharmacometrics Learning Resource supported by ACCP

187 Subject: [NMusers] Cone shaped DV-PRED

188 Subject: [NMusers] addition of dummy points

189 Subject: [NMusers] gradient/significant digit/Cov step

190 Subject: [NMusers] NONMEM convergence criterion

191 Subject: [NMusers] Residuals and INTERACTION for simultaneous PK/PD, impossible?

192 Subject: [NMusers] simulation of dose escalation study

193 Subject: [NMusers] population size and confidence power

194 Subject: [NMusers] San Francisco Bay Area PK/PD network

195 Subject: [NMusers] AUC computation using noncompartmental method

196 Subject: [NMusers] Difference between typical values and geometric mean of posthoc values

197 Subject: [NMusers] dose compartment

198 Subject: [NMusers] Window of absorption

199 Subject: [NMusers] Revised NMTRAN buglist [14MAR2005]

200 Subject: Am I interpreting THETA(1) incorrectly?

201 Subject: [NMusers] Any way to change the maximum input data item no.?

202 Subject: [NMusers] Any way to change the maximum input data item no.?

203 Subject: [NMusers] PK/PD Plots in a Label

204 Subject: [NMusers] NONMEM questions

205 Subject: [NMusers] Modeling of different formulations

206 Subject: [NMusers] Random sampling times

207 Subject: [NMusers] Modelling twitch potentiation in NONMEM, problems with $DES

208 Subject: [NMusers] Pre-release of PsN version 2.2

209 Subject: [NMusers] Plcebo Corrected PK/PD

210 Subject: [NMusers] Model building question

211 Subject: [NMusers] NONMEM question.

212 Subject: [NMusers] New NMTRAN bug list with a new Bug # XXVIII

213 Subject: [NMusers] Difficulty with ADVAN6

214 Subject: [NMusers] Error message: floating divide by zero

215 Subject: [NMusers] Installation of NONMEM

216 Subject: [NMusers] problem about enterohepatic circulation model. Thanks!!!!

217 Subject: [NMusers] WinNonmix code

218 Subject: [NMusers] new buglist for NMTRAN 07FEB2005

219 Subject: [NMusers] $DES and T

220 Subject: [NMusers] Simulated PD value at time zero

221 Subject: [NMusers] Indirect response PD model

222 Subject: [NMusers] questions on ODE solver errors

223 Subject: [NMusers] Missing data, MDV and PCMT

224 Subject: [NMusers] question re: % time spent modeling

225 Subject: [NMusers] Update for NONMEM bug XII

226 Subject: [NMusers] Number of subject and population PK/PD modeling

227 Subject: [NMusers] R scripts for NM output tables

228 Subject: [NMusers] MSFI issue - apparent state: unit 3 named

229 Subject: [NMusers] How does NONMEM $DES work?

230 Subject: [NMusers] pediatric PK studies for pediatric exclusivity

231 Subject: [NMusers] SAS vs S-Plus

232 Subject: [NMusers] SAS program or SAS macro to prepare NonMem ready data

233 Subject: [NMusers] posthoc step

234 Subject: [NMusers] problem with simulation

235 Subject: [NMusers] Determining metabolite clearance fraction

236 Subject: [NMusers] Model estimate of dose

237 Subject: [NMusers] Permutation test with small number of possible permutations

238 Subject: [NMusers] Simulation problem

239 Subject: [NMusers] When should a long run be aborted?

240 Subject: [NMusers] NONMEM Bug Overview - AAPS

241 Subject: [NMusers] Something wrong in US FDA guidance?

242 Subject: [NMusers] PD lag time in $DES

243 Subject: [NMusers] Negative values in 95%CI on ETAs

244 Subject: [NMusers] Updated NMTRAN bug VIII

245 Subject: [NMusers] sample size

246 Subject: [NMusers] Open note to Nick Holford about WFN installation subdirectories

247 Subject: [NMusers] Apple G5

248 Subject: [NMusers] Electronic submission to JPKPD

249 Subject: [NMusers] Problem in loading NONMEM software

250 Subject: [NMusers] Most important papers in PopPK

251 Subject: [NMusers] Visual NONMEM error

252 Subject: [NMusers] Missing Covariate values

253 Subject: [NMusers] Modeling with insufficient data

254 Subject: [NMusers] Seconds in NONMEM

255 Subject: [NMusers] NONMEM troubleshoot

256 Subject: [NMusers] allometric scaling

257 Subject: [NMusers] Update for NONMEM bug list October 13, 2004

258 Subject: [NMusers] Error message

259 Subject:[NMusers] Avoiding ABORT in NONMEM Initialization

260 Subject: [NMusers] saturable first-pass metabolism

261 Subject: [NMusers] Urinary excretion

262 Subject: [NMusers] Modelling individual data using a data file on several subjects

263 Subject: [NMusers] BOV

264 Subject: [NMusers] covariates

265 Subject: [NMusers] Interoccassion variability and Auto-induction model

266 Subject: [NMusers] Log transformation

267 Subject: [NMusers] NONMEM dataset development

268 Subject: [NMusers] WRES vs. time

269 Subject: [NMusers] Drug initially inhibits one enzyme and then the second enzyme isinduced

270 Subject: [NMusers] Does EVID=4 reset the baseline too?

271 Subject: [NMusers] Indirect response model in NONMEM

272 Subject: [NMusers] Decrease in OFV with a fixed effect

273 Subject: [NMusers] NONMEM Bug VII

274 Subject: [NMusers] indirect response model

275 Subject: [NMusers] Outliers and the FDA guideline

276 Subject: [NMusers] BUGLIST ERROR

277 Subject: [NMusers] NMPRD4 or LNP4 too small Error

278 Subject: [NMusers] Modeling of iv and po data


280 Subject: [NMusers] "First-pass" 3-compartment model

281 Subject:[NMusers] Changing Clearance over time : Enzyme auto-induction

282 Subject: [NMusers] Simultaneous model of plasma and whole blood data

283 Subject: [NMusers] ADVAN12

284 Subject: [NMusers] Non-Influential Eta Bug

285 Subject: [NMusers] calculation of time-to-nadir

286 Subject: [NMusers] SIMULATION SUBPROBLEM generated ID number

287 Subject:[NMusers] Software: regulatory compliance

288 Subject:[NMusers] help needed - nonlinear absorption

289 Subject:[NMusers] Further on the handling of missing data

290 Subject: [NMusers] Coding for missing data values

291 Subject: [NMusers] protein binding

292 Subject: [NMusers] Combined exponential + differential equations in $DES for post-SS concentrations

293 Subject: [NMusers] Renal CL estimations

294 Subject:[NMusers] CLS method

295 Subject: [NMusers] How sparse is too sparse?

296 Subject: [NMusers] FW: [BUGS] SERIOUS WARNING: Potential error in interpreting

297 Subject: [NMusers]info on a do-while-loop

298 Subject: [NMusers] POP PK study in pediatrics

299 Subject: [NMusers] $OMEGA blocks and log-likelihood profiling

300 Subject: [NMusers] PK models for rich and sparse sampling

301 Subject:[NMusers] Fx

302 Subject: [NMusers] Mixture model with Pk parameter changing with time

303 Subject: [NMusers] Mixture Models

304 Subject:[NMusers] Multiple Dosing-EVID or ADDL?

305 Subject:[NMusers] Multiple Dosing

306 Subject: [NMusers] posthoc estimates

307 Subject: [NMusers] NONMEM Estimation algorithms

308 Subject: [NMusers] Constant and Proportional Error with Log transformed data with single data point per subject

309 Subject: [NMusers] problem with acquiring post hoc estimates

310 Subject: [NMusers] NONMEM Tips #20 - Apr 29, 2004 - Notes on changing NONMEM V *SIZE S parameters

311 Subject: [NMusers] Trouble increasing ETA capacity in NMV 1.1

312 Subject:[NMusers] Need advice

313 Subject: [NMusers] Revised NMTRAN buglist - 26APR2004

314 Subject: [NMusers] no. of dummy points affect simulation and estimation results

315 Subject: [NMusers] error message: Number of evaluations of differential equations

316 Subject: [NMusers] Suggestions for the Official Bug List

317 Subject:[NMusers] SCAT

318 Subject: [NMusers] RE: steady state dosing

319 Subject: [NMusers] Trouble with Verbatim code

320 Subject: [NMusers] PD interaction between two substances

321 Subject: [NMusers] Literature on PK/PD modeling with two data points (baseline and end of study duration)

322 Subject: [NMusers] materials/Slides for population (PK/PD) analysis education to statisticians

323 Subject: [NMusers] Combined tissue and plasma concentration models

324 Subject: [NMusers] Simulations: Can subject specific initial values be used?

325 Subject: [NMusers] SOP on PopPK analysis

326 Subject: [NMusers] time-controlled drug delivery

327 Subject: [NMusers] Estimation Methods-HELP!!

328 Subject: [NMusers] FWORK ERROR

329 Subject: [NMusers] Wings of NONMEM (WFL)

330 Subject: [NMusers] Additions to the GloboMax ftp and web sites

331 Subject: [NMusers] The Official NONMEM V Bug List

332 Subject: [NMusers] CLS routines called in $DES to obtain the individual's plasma concentration predictions

333 Subject: [NMusers] Implementation of interindividual variability in residual variance

334 Subject: [NMusers] NONMEM code changes

335 Subject: [NMusers] Modeling average data

336 Subject: [NMusers] ADVAN2 and ADVAN6: biased results

337 Subject: [NMusers] Fortran overflow

338 Subject: [NMusers] Use of PREDPP

339 Subject: [NMusers] Number of compartments

340 Subject: [NMusers] Simulated vs. fitted population concentration curves

341 Subject: [NMusers] some issues about NONMEM

342 Subject: [NMusers] Time of day as a covariate

343 Subject: [NMusers] Simulation problems

344 Subject: [NMusers] simulation

345 Subject: [NMusers] Error modeling

346 Subject: [NMusers] NONMEM Tips #19- Jan 8, 2004 - Notes of the Installation and use of NONMEM V with Intel Fortran 8.0 for Windows

347 Subject: [NMusers] NONMEM and symbols

348 Subject: [NMusers] Fitting Data Below the Quantification Limit

349 Subject: [NMusers] Question re: indirect model

350 Subject: [NMusers] Simulation (patient) number

351 Subject:[NMusers] Fixed elements within a block covariance matrix


353 Subject: [NMusers] AR(1) residuals

354 Subject:[NMusers] Scaling of pharmacokinetics in peds

355 Subject: [NMusers] Nonmem model

356 Subject: [NMusers] Omission in NONMEM CD-ROM readme.doc

357 Subject: [NMusers] g77 optimization fails with current versions

358 Subject: [NMusers] BOV Code

359 Subject: [NMusers] Epsilons correlated across L2 records

360 Subject: [NMusers] Population PK model for Incomplete Block Design

361 Subject: [NMusers] interpretation of WRES of logarithmically transformed data

362 Subject: [NMusers] Applications of PK Principles in Drug Development / TOC

363 Subject: [NMusers] modeling interoccasion variability

364 Subject:[NMusers] Emax modeling question

365 Subject: [NMusers] Different population estimates

366 Subject: [NMusers] How to do simulation?

367 Subject: [NMusers] Error message: NO MORE THAN 20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ~

368 Subject: [NMusers] Addresses for Globomax NONMEM and PDx-Pop Support

369 Subject: [NMusers] Creating predicted Cp's within NONMEM

370 Subject: [NMusers] lagged concentrations

371 Subject: [NMusers] Partial Derivatives

372 Subject: [NMusers] NONMEM Tips #18 - Oct 22, 2003 - Alison's nmsee5 for summarizing NONMEM output

373 Subject: [NMusers] Forrtl: error(72): floating overflow?

374 Subject: [NMusers] Filing

375 Subject: [NMusers] LLR test, AIC, BIC

376 Subject:[NMusers] Initial estimates query

377 Subject: [NMusers] Number of Data Items in a Record

378 Subject:[NMusers] modeling compartments within compartments

379 Subject: [NMusers] 1 simple question from a nmbeginner

380 Subject: [NMusers] Two simple questions

381 Subject: [NMusers] order of covariate inclusion

382 Subject: [NMusers] order of covariate inclusion

383 Subject: [NMusers] Simulating large number of samples

384 Subject: [NMusers] Oral partitioned dose

385 Subject:[NMusers] Model estimates based on 1 samle per subject

386 Subject: [NMusers] Simultaneous Running of nmfe5

387 Subject: [NMusers] increasing ETA estimates with adding full block

388 Subject: [NMusers] Simulation with IOV

389 Subject: [NMusers] Calculation of WRES...

390 Subject: [NMusers] Estimation and Simulation

391 Subject: [NMusers] TVKa>TVKe or Ka>Ke?

392 Subject: [NMusers] Non-physiological parameters at lowest OBJ

393 Subject: [NMusers] Nonmem DV and IPRED

394 Subject:[NMusers] initial condition model

395 Subject: [NMusers] t-distribution in NONMEM?

396 Subject: [NMusers] Parameter %RSE vs ETA %RSE

397 Subject: [NMusers] Metropolis-Hastings vs Gibbs sampling in PKBugs

398 Subject:[NMusers] FO vs FOCE vs LAPLACIAN

399 Subject: [NMusers] Bootstrapping

400 Subject: [NMusers] nlmeODE package combining NLME with a differential equation solve

401 Subject: [NMusers] Hessians of posterior density

402 Subject: [NMusers] Omega Block off Diagonals

403 Subject: [NMusers] RACE as a covariate

404 Subject: [NMusers] PRED in a Hill binding model

405 Subject: [NMusers] simulate different degrees of sample sparsity

406 Subject: [NMusers] Watcom compiler

407 Subject: [NMusers] When is PK not needed

408 Subject: [NMusers] Xpose has moved

409 Subject:[NMusers] WFN for UNIX/Linux

410 Subject:[NMusers] Regulatory Guidelines

411 Subject: [NMusers] DV simulation problem

412 Subject: [NMusers] Weighting in NONMEM

413 Subject: [NMusers] Obj. function is infinite (error=136)

414 Subject: Re: [NMusers] DV Simulation

415 Subject: [NMusers] Poor PRED estimates

416 Subject:[NMusers] DV Simulation

417 Subject: [NMusers] NONMEM Tips #17 - May 19, 2003 - A Word Macro for Reformatting NO NMEM Output

418 Subject: [NMusers] Math problem

419 Subject: [NMusers] problem with number of ETA's

420 Subject: [NMusers] correlation function for the epsilons

421 Subject: [NMusers] ROUNDING ERRORS (ERROR=134)

422 Subject:[NMusers] Correction to 1999 posting on between occasion variability

423 Subject: [NMusers] NONMEM under LINUX vs 21 CFR Part 11 compliance

424 Subject:[NMusers] Using covariates with positive and negative values

425 Subject: [NMusers] model diagnostics

426 Subject: [NMusers] Covariate analysis

427 Subject: [NMusers] Coding for Bioavailability

428 Subject: [NMusers] Error model

429 Subject: [NMusers] Mixture models in NONMEM

430 Subject: [NMusers] Handling of baseline

431 Subject:NMusers] Error model

432 Subject: [NMusers] Adaptive trial simulations using NONMEM

433 Subject: [NMusers] Single Precision NONMEM

434 Subject: [NMusers] NONMEM Tips #16 - April 2, 2003 - Modeling a "baseline" component and an additive "drug" component

435 Subject: [NMusers] Log-transformation

436 Subject: [NMusers] Watcom Open Source compiler...

437 Subject: [NMusers] Fixed or estimated?

438 Subject: [NMusers] WRES ve PRED plots

439 Subject: [NMusers] Describing variability

440 Subject: [NMusers] NONMEM Tips #15 - March 19, 2003 - NONMEM V using Open Watcom 1.0 Fortran for Windows

441 Subject: [NMusers] Ln(DV)

442 Subject:[NMusers] ADVAN 4TRANS4

443 Subject: [NMusers] separate parameter estimates

444 Subject:[NMusers] Multi-modal distribution of variability in NM

445 Subject:[NMusers] fundamental questions about NONMEM

446 Subject:[NMusers] Covariate effect

447 Subject:[NMusers] large CV

448 Subject:[NMusers] Michaelis-Menten model i nonmem

449 Subject:[NMusers] NONMEM and 21 CFR Part 11

450 Subject:[NMusers] simulated negative concentration

451 Subject:[NMusers] Outlier detection/exclusion in NONMEM

452 Subject: [NMusers] avoiding when ETA()=0

453 Subject: [NMusers] Change of default observations per individual

454 Subject: [NMusers] model for OMEGA and SIGMA

455 Subject:[NMusers] CV

456 Subject:[NMusers] interoccasion variability

457 Subject:[NMusers] Regression with errors in X

458 Subject:[NMusers] FO vs FOCE (Any test?)

459 Subject:[NMusers] Bioavailability and P-Gp

460 Subject:[NMusers] NONMEM Tips #14 - January 24, 2003 - A new setup file for installing NONMEM V with Intel Fortran 7.0 for Windows

461 Subject:[NMusers] Repeat administration with varying dose interval

462 Subject:[NMusers] reference for log-transformation

463 Subject:[NMusers] intel 7.0 on linux

464 Subject: [NMusers] Visual-NM

465 Subject:[NMusers] Intel Fortran 7 Compiler

466 Subject:[NMusers] When to study BOV?

467 Subject:[NMusers] "Extra file" option in XPOSE

468 Subject:[NMusers] Warning on xpose - S+ interaction

469 Subject:NONMEM Bug - Noninfluential Correlated Eta

470 Subject:[NMusers] weight as a covariate in kids

471 Subject:[NMusers] $DES : Initialising the value of A at time 0

472 Subject:[NMusers] Simulation with a uniform distribution by NONMEM

473 Subject:[NMusers] ADVAN3 vs ADVAN6

474 Subject: [NMusers] signficant covariate question

475 Subject: [NMusers] OMEGA HAS A NONZERO BLOCK

476 Subject:[NMusers] Increasing the number of THETAs

477 Subject:[NMusers] Error Message from NONMEM :: MINIMIZATION TERMINATED (ERROR=136)

478 Subject:[NMusers] Obtaining gradients for the computation of prediction intervals

479 Subject:[NMusers] Sensitivity analysis

480 Subject: [NMusers] NONMEM Tips #13 - August 26, 2002 - New Windows and UNIX Releases of Xpose available

481 Subject: [NMusers] Imputation of missing sex covariate

482 Subject:[NMusers] Placebo-corrected PD models

483 Subject:[NMusers] Confidence interval

484 Subject: [NMusers] Portland Group f77 compiler

485 Subject: [NMusers] Comparison of simulated trials to real trials

486 Subject: [NMusers] NMV on Pentium 4

487 Subject:[NMusers] Missing Gender (Categorical values)

488 Subject:[NMusers] Cl/F and V/F

489 Subject: [NMusers] $SCAT scale expansion

490 Subject:[NMusers] Changing signifocant digits

491 Subject:[NMusers] Y2K and the LAST20 Option

492 Subject: Laplacian Estimation Method with Mean-Variance Model and Interaction

493 Subject:[NMusers] Endogenous drug

494 Subject:[NMusers] Wrong model

495 Subject:[NMusers] Storing simulations

496 Subject:[NMusers] NONMEM Tips #12 - July 08, 2002 - NONMEM using g77 for Windows

497 Subject: [NMusers]

498 Subject:[NMusers] Metabolite kinetics help

499 Subject: [NMusers] Statistical power for AUC and Cmax

500 Subject:[NMusers] Linux

501 Subject: [NMusers] FW: [S] The effect of default values on statistical results

502 Subject:[NMusers] A simple question

503 Subject:[NMusers] Xpose error message

504 Subject:[NMusers] 2-cmpt PK model using ADVAN6

505 Subject:[NMusers] NONMEM help under Windows XP

506 Subject:[NMusers] Pop PK/PD integrated plus differential equations

507 Subject:[NMusers] how to capture minimum OFV in NM output TABLE

508 Subject:[NMusers] Enterohepatic Circulation!!!

509 Subject:[NMusers] Calling a uniform random variable in NONMEM

510 Subject:[NMusers] Several metabolites in urine

511 Subject:[NMusers] "Tip of the Week #11 - May 24 , 2002" - Solution to NONMEM Coding Challenge #2

512 Subject:[NMusers] NONMEM Wish List

513 Subject:[NMusers] Installing NONMEM in Win2K with gcc/g77 compiler

514 Subject:[NMusers] Asking about equation describing plasma concentration of metabolite after oral administration

515 Subject: [NMusers] "Tip of the Week #10 - May 13, 2002" log-transformed data and DV= 0 records [avoiding log(0)]???

516 Subject: [NMusers] Log-transformation

517 Subject:[NMusers] Oral pharmacokinetics sparse (no absorption phase)

518 Subject:[NMusers] Placebo-corrected PD models

519 Subject: [NMusers] nonmem installation on Linux

520 Subject: [NMusers] redhat linux for nonmem

521 Subject: [NMusers] sequential PK/PD

522 Subject: [NMusers] $COV

523 Subject: [NMusers] Two formulation of the same Drug

524 Subject: [NMusers] NONMEM runtimes

525 Subject: [NMusers] "Tip of the Week #9 - April 24, 2002" - modeling log-transformed data

526 Subject: [NMusers] what is behind $Simulation

527 Subject: [NMusers] When to do transformation of data?

528 Subject: [NMusers] nonmem

529 Subject: [NMusers] NMTRAN data truncation

530 Subject: [NMusers] covariate significance

531 Subject: [NMusers] "Tip of the Week #8 - April 16, 2002" - Sequential numbering in a TABLE

532 Subject: [NMusers] "Tip of the Week #7 - April 8, 2002" - subsetting your data 'on the fly'

533 Subject: [NMusers] Capturing AUC between observation time intervals

534 Subject: [NMusers] "Tip of the Week #6 - April 3, 2002" - Current contents of the NO NMEM Repository @

535 Subject: [NMusers] Significance?

536 Subject: [NMusers] Simultaneous modeling of PK and categorical PD

537 Subject: [NMusers] Approximate effect compartment

538 Subject: [NMusers] Problem in using $PRED

539 Subject: [NMusers] nonmem under cygwin

540 Subject: [NMusers] Model Validation

541 Subject: [NMusers] Digital Visual Fortran vers 5.0 vs 6.6 and NM-TRAN Bug

542 Subject: [NMusers] Problems with Digital Visual Fortran vers 5.0 on Windows NT 4.0

543 Subject: [NMusers] Concentration dependent volume of distribution

544 Subject:[NMusers] "Tip of the Week #5 - March 18, 2002" -submissions to nmusers mailing list -

545 Subject: [NMusers] NONMEM on LINUX

546 Subject:[NMusers] NONMEM vs NLMIXED

547 Subject:[NMusers] RE: T S R matrices

548 Subject:[NMusers] BOV and BSV

549 Subject:Re: [NMusers] T matrix

550 Subject:[NMusers] T matrix

551 Subject:[NMusers] EVID data item and beyond

552 Subject: [NMusers] Error message..

553 Subject:[NMusers] Error models

554 Subject: [NMusers] "Tip of the Week #4 - March 4, 2002" - Coding Time After Dose(TAD)

555 Subject: PK/PD problem using ADVAN6

556 Subject:[NMusers] Confidence intervals for Emax model

557 Subject:[NMusers] Dumping of internally used parameter values to file

558 Subject:[NMusers] Non-positive definite covariance matrix without warnings from Non

559 Subject:[NMusers] PD modeling question

560 Subject:[NMusers] "Tip of the Week #3 - February 25, 2002" - Coding Time After Dose

561 Subject:[NMusers] lag time

562 Subject:[NMusers] Calculation of AUC for multiple oral doses

563 Subject:[NMusers] Modeling of Blood flow data

564 Subject:[NMusers] Error Message: Initial Values for ATOL ?

565 Subject:[NMusers] Parallel absorption model (two lag times)


567 Subject:[NMusers] NONMEM Add-On Software Commercially Released

568 Subject:[NMusers] error models log domain

569 Subject:[NMusers] max no. of observation per subject

570 Subject:[NMusers] NONMEM crash?

571 Subject: [NMusers] "Tip of the Week #2 - January 23, 2002" - NONMEM Repository at Globomax

572 Subject: NONMEM testing set

573 Subject: Placebo data and weighting

574 Subject: censored data

575 Subject: Integrator option

576 Subject: "Tip of the Week #1"

577 Subject: [NMusers] local minimum

578 Subject: [NMusers] New Journal

579 Subject: [NMusers] Michaelis Menten kinetics

580 Subject: [NMusers] confidence interval

581 Subject: [NMusers] Microsoft Visual Fortran v5 and 2000?

582 Subject: [NMusers] Windows XP

583 Subject: [NMusers] mixture model

584 Subject: [NMusers] error message from $covariance

585 Subject: [NMusers] 3 compartment nonlinear pharmacokinetics model

586 Subject: [NMusers] FOCE objective function

587 Subject: [NMusers] NMSEE GUIDE

588 Subject: [NMusers] $MIX

589 Subject: [NMusers] Problem (bug ?) with RATE and F1 in $PK

590 Subject: [NMusers] Bayesian fits

591 Subject: [NMusers] glucose blood level measurements

592 Subject: [NMusers] Weight normailized doses in modeling

593 Subject: [NMusers] Simulation step

594 Subject: Unreasonable final estimated values

595 Subject: [NMusers] Announcement

596 Subject: g77 on HP/UX 11.0

597 Subject: Integrator options


599 Subject: Post treatment effect

600 Subject: LSIZES and TSIZES

601 Subject: Help with Windows 2000 and Digital Fortran 6.0

602 Subject: IV and oral code

603 Subject: NONMEM conc-reponse analysis for depression

604 Subject: Simulation of coinfused drugs

605 Subject: Minimum value of objective function..

606 Subject: Sequential absorption processes with lag time

607 Subject: Pharmacokinetics, allometry and flat earth theories

608 Subject: Non-zero peripheral drug amount

609 Subject: Coadministered drugs (PK-PD)

610 Subject: Setting Compaq FORTRAN environmental variables under Windows

611 Subject: 2-compartment model: V2 doesn't vary

612 Subject: Multiple dose levels

613 Subject: Scaled Transform Parameters

614 Subject: Feed-back PK-PD models

615 Subject: LOG...

616 Subject: Xpose and R

617 Subject: Repository

618 Subject: FYI - MEM for binary response with one obs/individual

619 Subject: logistic regression


Subject: Distributive Computing

621 Subject: NONMEM V on SUN f90

622 Subject: Dataset

623 Subject: Help: oral and ig bioavailability by NONMEM

624 Subject: Averaged peripheral concentration

625 Subject: weighting

626 Subject: NONMEM error msg

627 Subject: End-of-file error

628 Subject: MSDOS versus VisualNM

629 Subject: S-matrix and RNGs

630 Subject: NONMEM installation on Windows Me

631 Subject: $SIMULATION

632 Subject: Help: Non-positive semi-definite message

633 Subject: NONMEM users repository - (

634 Subject: Conversion of micro constants to macro constants

635 Subject: NONMEM Timeline

636 Subject: Rounding Error 134

637 Subject: Help on simulation mode

638 Subject: Error message 72

639 Subject: XPOSE error message

640 Subject: PRED VS WRES

641 Subject: One vs two compartments

642 Subject: minimization termination

643 Subject: Different models for different age groups? Infinite objective functions

644 Subject: FO, FOCE, FOCE w/ interaction reference

645 Subject: Error message in $COV step

646 Subject: Centering (was Re: Missing covariates)

647 Subject: Missing covariates

648 Subject: Combining the results after multiple imputation

649 Subject: Transformations of data

650 Subject: BQLs

651 Subject: Characters in error are: FWORK

652 Subject: High performance FORTRAN

653 Subject: Covariate screening


655 Subject: Increasing the umber of sub-population in a mixture model

656 Subject: Slow Gradient Method.

657 Subject: Error models and weighting

658 Subject: PRED values

659 Subject: Mixture model at the IOV level?

660 Subject: Error Messgae

661 Subject: Samples for external validation

662 Subject: Changing number of observations per indivdual record.

663 Subject: Autoinduction

664 Subject: How to reset the limit for number of THETAs (TSIZES)?

665 Subject: Rich data set

666 Subject: CELS error message

667 Subject: Absoft pro Fortran 7.0

668 Subject: Parameterization!!!

669 Subject: Multiple Doses

670 Subject: ENTIRE RECORD IS BLANK & prediction values are zero

671 Subject: Parameterization!!!

672 Subject: One ETA...for which parameter?

673 Subject: ADVAN10

674 Subject: Unreasonable VSS estimate

675 Subject: ETAs constructed from observed data

676 Subject: Nonmem Text book

677 Subject: NONMEM priority on windows NT/2000

678 Subject: NONMEM compliance

679 Subject:

680 Subject: residual error model, endogeneous drug

681 Subject: The number of columns (variables) in $INPUT block

682 Subject: How to perform integer operations in NONMEM

683 Subject: Suspicious CL/F vs. CLCR and SGOT values

684 Subject: Exponent in sigmoid Emax model and ETA

685 Subject: question with running nonmem

686 Subject:constant CV


688 Subject: parent drug & metabolite

689 Subject: prediction testing

690 Subject: problem with AUC

691 Subject: negative objective value

692 Subject: zero order absorption

693 Subject: Lag Time Problem

694 Subject: Large components in gradient vector

695 Subject: Data Construct / ADVAN selection

696 Subject: NONPAR

697 Subject: Validation / Mean Predictive Error

698 Subject: Rounding errors / $SIM superproblem

699 Subject: Rounding errors / $SIM superproblem

700 Subject: Bootstrap resampling!

701 Subject: NM performance on AMD athlon vs. Intel P4 (or P3)

702 Subject: Syntax for POSTHOC option

703 Subject: Increasing number of obs per subject

704 Subject: Residual Error

705 Subject: negative objective function values

706 Subject: nonmem V 1.1 and apogee compiler

707 Subject: WinNonlin compatible with DVF ?


709 Subject: SIGMA estimates

710 Subject: Maximizing coefficient of determination

711 Subject: RE: Help please...

712 Subject: population pharmacokinetic designs

713 Subject: Plasma and urine

714 Subject: Covariate: statistical vs clinical

715 Subject: Question for Non-Compartment Anaylsis

716 Subject: Question on Bias est. and the conditional method

717 Subject: Help please...

718 Subject: Correlations for power analysis

719 Subject: fortran question

720 Subject: Rate constants

721 Subject: Stepwise regression

722 Subject: msg from atul

723 Subject: 95% CI of paramter estimate

724 Subject: Simulation wiht off Diagonal elements

725 Subject: win 2000

726 Subject: questions..

727 Subject: PD initialization

728 Subject: Bayesian estimation

729 Subject: Correct codes of modeling Michaelis-Menten elimination using concentration-time data

730 Subject: NM-EXTRACTOR, a PC software to export parameters from NONMEM output files

731 Subject: Mac question

732 Subject: Weight as Covariate

733 Subject: FW: FORTRAN compiler for use with NONMEM

734 Subject: MS Fortran PowerStation v. 4 under Win 2000

735 Subject: Error-out of Environment space

736 Subject: Initial conditions for amounts in compartments

737 Subject: missing data items

738 Subject: Warning: NMTRAN does not interpret conditional abbreviated code properly

739 Subject: Warning: NMTRAN does not interpret conditional abbreviated code properly

740 Subject: IOV and Physiological Variables

741 Subject: IOV and Physiological Variables

742 Subject: Caution with verbatim code/RE: Number of evaluations of differential equations

743 Subject: problem with increasing the number of eta's by changing LVR

744 Subject: PD analysis without PK data

745 Subject: One more way to approach the problem of interindividually varying SIGMA

746 Subject: Number of evaluations of differential equations

747 Subject: [Fwd: CLIN PHAR STAT: Mixed Vs Fixed]

748 Subject: [Fwd: CLIN PHAR STAT: Mixed Vs Fixed]

749 Subject: test of differences between posthocs

750 Subject: Compilation headaches

751 Subject: Response is sum of amounts

752 Subject: Allometric scaling

753 Subject: weighted residuals

754 Subject: RE: centering / maximum function evals

755 Subject: drug levels in saliva

756 Subject: IV and ORAL data fitted simultaneously

757 Subject: Sample Size

758 Subject: weighting observed data

759 Subject: Simulations for Bioequivalence testing

760 Subject: Software and procedures for conducting and reporting on NONMEM analyses in clinical reports

761 Subject: meaning of LWS1 in NSIZES

762 Subject: problem advan4 trans4

763 Subject: NONMEM slow on DEC Alpha?

764 Subject: Validation of models for categorical data

765 Subject: Predictive Performance

766 Subject: Model building algorithm

767 Subject: g77 compiler under DOS


769 Subject: zero order and bolus input

770 Subject: NONMEM on AIX

771 Subject: I am interested in using NONMEM in the analysis of binary data but I don't want to use the standard

772 Subject: Nested random effects with NONMEM?

773 Subject: ADVAN4!!!

774 Subject: Inter occasion variability

775 Subject: Repeating cases

776 Subject: Monte Carlo simulations with NM

777 Subject: NONMEM under Windows 2000

778 Subject: Modeling Queues

779 Subject: Hepatic Insufficiency

780 Subject: Optimal sampling points

781 Subject: Optimal sampling points

782 Subject: Coding problem

783 Subject: NONMEM Installation

784 Subject: metabolite modelling

785 Subject: NONMEM Consultation Support

786 Subject: Citations in the NONMEM Users Archive

787 Subject: Classification of concomitant medication

788 Subject: IOV effects (inter-occasion variability)

789 Subject: Prediction intervals

790 Subject: Cross product matrix

791 Subject: Predicted Concetration derivations

792 Subject: repeating cases

793 Subject: Re: Covariate Models Using Weight

794 Subject: Re: Covariate Models Using Weight

795 Subject:Covariate Models Using Weight

796 Subject:Covariate Models Using Weight

797 Subject: Covariate Models Using Weight (origination of the above four threads)

798 Subject: Error (72) - Overflow

799 Subject: Simulation

800 Subject: Computing std for secondary parms

801 Subject: FW: NONMEM & HP

802 Subject: absorption lag parameter specification

803 Subject: $SCATTER question

804 Subject: ADVAN3 TRANS3 Problem

805 Subject: Compaq Visual Fortran

806 Subject: Equal variance between and within subjects

807 Subject: Compilation on Linux

808 Subject: Dose event problem

809 Subject: Modification of the File, nmfe5.bat?

810 Subject: ? Emptying the Gall Bladder in NONMEM

811 Subject: Visual-NM

812 Subject: NONMEM

813 Subject: treatment of BQL

814 Subject: Forecasting Individual PK and PD

815 Subject: NONMEM Installation

816 Subject: FORTRAN compiler for use with NONMEM

817 Subject: LAST DOSE

818 Subject: Variance of the predictions of the etas.

819 Subject: NONMEM Installation

820 Subject: NONMEM Analysis Strategy

821 Subject: Interoccasion variability

822 Subject: Fitting 2 compartment first-order input PK/PD model.

823 Subject: SPlus

824 Subject: What does "CENTERING" do?

825 Subject: NonMem & Y2K

826 Subject: Re: NONMEM installation

827 Subject: Error message

828 Subject: Computer and compiler questions

829 Subject: Version of Digital Visual Fortran

830 Subject: BQL values, version 3

831 Subject: Simulation in Drug Development: Good Practices: CDDS

832 Subject: Analysis of sparse data

833 Subject: Blank data points

834 Subject: Error message

835 Subject: derivative-free quasi-Newton type minimization algorithm

836 Subject: Drug-metabolite kinetics

837 Subject: Steady-state equation

838 Subject: Compiler Information

839 Subject: time variant covariate ?

840 Subject: installation of NONMEM on HP platform

841 Subject: implementation of cosine function

842 Subject: Fortran errors

843 Subject: Modeling of inter study variability (ISV) as a third random effect level

844 Subject: Question: Number of ETA and EPS in statistic significance

845 Subject: References on NONMEM application

846 Subject: Statistics books on statistical theory in NONMEM

847 Subject: 'MAIN__'

848 Subject: NONMEM initial licensing fees

849 Subject: NONMEM installation

850 Subject: Station Speed question

851 Subject: Windows 98

852 Subject: flip-flop kinetics


854 Subject: comparing theta's

855 Subject: Input variable to NRECS in $DATA record?

856 Subject: Translation from CL,V etc. to alpha, etc.

857 Subject: offsets - Centering covariates

858 Subject: Validation

859 Subject: PREDvsDV

860 Subject: Request for Advice re NONMEM UNIX Configuration

861 Subject: Error model

862 Subject: Two abosorption periods from a single dose??

863 Subject: full covariance matrix

864 Subject: Is size of database limited?

865 Subject: Dble exponential error model

866 Subject: Population compliance model

867 Subject: concomitant runs - NM 5 - Open VMS

868 Subject: Non-constant parameter

869 Subject: multiple drug cassettes or cocktails

870 Subject: Linux speed and optimization options

871 Subject: 2cmp MM

872 Subject: RE: How to calculate confidential interval of a plasma conc. curve

873 Subject: NONMEM as a dll

874 Subject: minimum objective function

875 Subject: Time-to-event

876 Subject: Statitical Help

877 Subject: NONMEM/SGI support

878 Subject: NONMEM V on VMS

879 Subject: Dr. Joachim Grevel's Population PK course

880 Subject: Bioequivalence question

881 Subject: Database?

882 Subject: Negative objective functions

883 Subject: stepwise zero order input

884 Subject: Modelling Workshop

885 Subject: NONMEM ERROR

886 Subject: ADVAN9: error in LSODI1: CODE 205

887 Subject: Post-hoc distributions

888 Subject: ADVAN 6

889 Subject: stepwise zero order process

890 Subject: Enterohepatic Recirculation Model

891 Subject: Residuals

892 Subject: 4Comp.mod.

893 Subject: Box-Cox transformation in NONMEM

894 Subject: ordinal dependent models

895 Subject: Control file

896 Subject: indirect PK-PD model and lag-time

897 Subject: NONMEM V and Power Macs

898 Subject: Nonmem and Fortran under Windows NT

899 Subject: Estimation of Lidocaine PK parameters using NONMEM

900 Subject: Help! - Conversion of Unix-Splus postscript graphic files to Word

901 Subject: FOCE

902 Subject: multitasking

903 Subject: $COV/$SIMULATION w/ subproblems

904 Subject: Viewing intermediate output from the estimation step

905 Subject: help with ALPHA compiler please

906 Subject: Visual Fortran Pro

907 Subject: Correlated Epsilons Across L2 Records

908 Subject: testing nmV / build2.bat file

909 Subject: nonpositive value for CL / abort

910 Subject: NONMEM V on Alpha 4100

911 Subject: Intel's Fortran Compiler

912 Subject: NONMEM Installation/FORTRAN Compiler - PC

913 Subject: Q:$DES with a lagged zero-order bolus dose

914 Subject: nmsee for NONMEM V

915 Subject: error message with a 3 comp model

916 Subject: Change in mail software

917 Subject: CI for individual predictions

918 Subject: Parameterization differences

919 Subject: outputting covariance matrix

920 Subject: converting epsilon to CV

921 Subject: contr.f and ccontr.f

922 Subject: Covariate Model Selection

923 Subject: Predictive performance at different concentrations

924 Subject: NONMEM & Splus 3.3 and 3.4

925 Subject: NM-WIN

926 Subject: Verbatim Code

927 Subject: Best Fortran compiler?

928 Subject: error at initial obj. function evaluation

929 Subject: Logistic Mixed models with NONMEM

930 Subject: Survival analysis in NONMEM

931 Subject: Bootstrap sampling

932 Subject: Multiple problems

933 Subject: Error trap

934 Subject: NONMEM and identification of drug-drug interactions

935 Subject: Digital Visual FORTRAN floating point exception handling?

936 Subject: NONMEM and Windows NT.

937 Subject: CR formulations

938 Subject: NT remote control

939 Subject: Bioavailability and Zero Order Infusions

940 Subject: Weighted Residuals Calculation

941 Subject: modeling steady state-constant infusion data

942 Subject: FDA draft guidance

943 Subject: Log Normal data

944 Subject: Problem with multiple dose input

945 Subject: Choosing between conditional estimation methods

946 Subject: Reply: Request for help about M-M kinetics

947 Subject: Nonmem seems to hang itself/Powers - floating-point exception error

948 Subject: NONMEM under DEC Alpha server

949 Subject: Software for PCs

950 Subject: arterio-venous modeling

951 Subject: Computation of CV's from OMEGA

952 Subject: Request for help about M-M kinetics

953 Subject: Visual-NM

954 Subject: Re: Logistic regression

955 Subject: hp-ux 10.20

956 Subject: Interspecies scaling

957 Subject: model building question

958 Subject: enterohepatic cycle modeling using nonmem

959 Subject: Weighted residuals calculation

960 Subject: OMEGA and SIGMA in INFN

961 Subject: Re: Early Unblinding in Phase III

962 Subject: DIGITAL Visual Fortran 5.0

963 Subject: Posthocs

964 Subject: which fortran compiler to choose (fwd)

965 Subject: Simulation Software

966 Subject: converting to alpha

967 Subject: NONMEM Consultant List

968 Subject: Residual variability

969 Subject: Sample size

970 Subject: Intel Pentium Pro and Pentium II error

971 Subject: covariate models

972 Subject: quest re delta clearance vs indep var

973 Subject: NPML-fit

974 Subject: Count model

975 Subject: useful smoking and alcohol information

976 Subject: Concentration values below assay limits

977 Subject: Year 2000

978 Subject: DIGITAL Fortran 5.0

979 Subject: user-code and Microsoft PowerStation 4

980 Subject: Normalization of PK parameters

981 Subject: 3 compartment model TRANS and ADVAN

982 Subject: fortran compiler

983 Subject: NONMEM and Linux

984 Subject: NM-win for windows 95

985 Subject: Problem accessing VMS log files from NONMEM runs.

986 Subject: Lag time

987 Subject: C-Shell

988 Subject: Any tools for Bayesian estimation?

989 Subject: data input

990 Subject: include lines

991 Subject: Printing NONMEM output files

992 Subject: Two-comp Michaelis-Menten elimination

993 Subject: CrossGraphs

994 Subject: Blinding Issues

995 Subject: DEC alpha chip

996 Subject: Discrete parameters

997 Subject: fortran errors

998 Subject: NONMEM running on Windows NT

999 Subject: NONMEM on Pentium

1000 Subject: New Software

1001 Subject: Sun Ultra 1 performance

1002 Subject: Deriving Cmax and the corresponding variability

1003 Subject: nmsee

1004 Subject: Confidence limits and predictive performance

1005 Subject: Weights for AUC in a logistics regression

1006 Subject: Modeling data with error in X & Y

1007 Subject: Beware: MS FORTRAN Powerstation 1.0

1008 Subject: strange error

1009 Subject: NONMEM COURSE

1010 Subject: kinetic interpolation and effect compartments

1011 Subject: new program

1012 Subject: NONMEM-Benchmark on DEC UNIX/alpha

1013 Subject: ViViD Visualization software - FREE!!

1014 Subject: New Software

1015 Subject: NONMEM Performance Notes for Silicon Graphics Platforms

1016 Subject: LOG(F) Error Model/Machine Differences

1017 Subject: ADVANs for 3-compartments

1018 Subject: Sample a Weighted combination of 2 compartments

1019 Subject: Installation

1020 Subject: Design Evaluation for PK Substudies in Phase III

1021 Subject: NONMEM and WindowsNT

1022 Subject: PK-PD using 2 step approach

1023 Subject: OUTPUT

1024 Subject: HP-UX upgrade

1025 Subject: NONMEM in drug development

1026 Subject: Announcing Xpose

1027 Subject: LOG of zero or negative error

1028 Subject: Clinical Trials

1029 Subject: NONMEM on DEC Alpha 500

1030 Subject: NONMEM, Windows 95, and Powerstation 4.0

1031 Subject: Exp function MATH overflow

1032 Subject: NONMEM on PC

1033 Subject: Cosine function

1034 Subject: PK/PD of 2 co-infused agents

1035 Subject: Requesting a larger number of significant digits

1036 Subject: Recommendations for Computing Hardware for NONMEM

1037 Subject: FORTRAN error

1038 Subject: NONMEM System Requirements

1039 Subject: How to fix elements of the OMEGA and SIGMA matrices

1040 Subject: PK/PD analysis

1041 Subject: Windows NT

1042 Subject: problems with NONMEM and windows 3.1

1043 Subject: Sampling Methods; need data

1044 Subject: PK-PD Modelling

1045 Subject: modelling flow-dependent clearance

1046 Subject: nonmem on Digital UNIX/alpha

1047 Subject: RESET HESSIAN

1048 Subject: Modelling adverse effects

1049 Subject: NONMEM platform versions

1050 Subject: Using $DES with COS Function

1051 Subject: Estimating Rates and effects of Drug X

1052 Subject: Negative values for ETA

1053 Subject: NONMEM on Macintosh's


1055 Subject: Residuals in NONMEM

1056 Subject: determination of Cmax and formulation effects

1057 Subject: FO versus FOCE

1058 Subject: Fitting a Log-Normal 1st-Stage Error Model using PREDPP or PRED

1059 Subject: Use of PREDPP to compute Effect Site or Metabolic Concentration in Conjunction with Using Analytical Linear ADVAN's.

1060 Subject: Installing NONMEM on Open VMS for Alphas...

1061 Subject: TIME ZERO CONC

1062 Subject: FO or FOCE?

1063 Subject: NONMEM on the PowerMac

1064 Subject: NM-Tran under Windows NT

1065 Subject: nm_report in NONMEM repository

1066 Subject: Data from multiple hospitalizations

1067 Subject: fitting PD alone

1068 Subject: NONMEM Repository (Post-Processor Program)

1069 Subject: modeling fast and slow absorption

1070 Subject: simulation

1071 Subject: -big option on PC

1072 Subject: NONMEM Repository

1073 Subject: Re: NONMEM on the PowerMac

1074 Subject: Akaike information criterion

1075 Subject:

1076 Subject:

1077 Subject:

1078 Subject:

1079 Subject: